Deborah Berke Partners, in collaboration with executive architect Polk Stanley Wilcox, designed the Bentonville, Arkansas, branch of mini-chain 21c Museum Hotel with a glass facade and 12,000 square feet of public exhibition space. In 2006, Berke was hired by owners Laura Lee Brown and Steve Wilson to design the first 21c Museum Hotel in Louisville, Kentucky: a series of "five deteriorating 19th century buildings along West Main Street with a design that highlighted the original brick, timber, and cast iron construction."