Lissoni began his career in 1978 having gained his architecture degree at the Milan Polytechnic and in 1985 started with Boffi Kitchens as Art Director & Designer. With Nicoletta Canesi he founded the architectural firm Lissoni Associates in Milan in 1986, and ten years later lent his vision to Graph.x, a graphic design company. As well as designing furniture, kitchens, bathrooms and lighting fixtures, he is also a premier art director, focusing on corporate identity, signage and packaging.